Tetrahydrofuran → cis-3-(4-Chloro-5-iodopyrrolo[2,3-d]pyrimidin-7-yl)-cyclobutanecarboxylic acid methyl ester

HRID 942981Notes

Reaction equation

HRID 942981 reaction equation
[CH2:35]1[O:36][CH2:37][CH2:38][CH2:39]1.[CH3:12][O:13][C:14](=[O:15])[CH:16]1[CH2:17][CH:18]([OH:20])[CH2:19]1.[Cl:1][c:2]1[c:3]2[c:4]([n:5][cH:6][n:7]1)[nH:8][cH:9][c:10]2[I:11].[O:21]=[C:22]([O:23][CH:24]([CH3:25])[CH3:26])[N:27]=[N:28][C:29]([O:30][CH:31]([CH3:32])[CH3:33])=[O:34]>>[Cl:1][c:2]1[c:3]2[c:4]([n:5][cH:6][n:7]1)[n:8]([CH:18]1[CH2:17][CH:16]([C:14]([O:13][CH3:12])=[O:15])[CH2:19]1)[cH:9][c:10]2[I:11]

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 75555Diisopropyl diazene-1,2-dicarboxylateHCID 12815112Cyclobutanecarboxylic acid, 3-hydroxy-, methyl esterHCID 148092816-Chloro-7-iodo-7-deazapurine

Product 1

HCID 57680882cis-3-(4-Chloro-5-iodopyrrolo[2,3-d]pyrimidin-7-yl)-cyclobutanecarboxylic acid methyl ester

Sources & evidence

ORD record
ord-16b3c96dc8e646329537054184fd09d6
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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