Ethanol → 2-methyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenol

HRID 943014Notes

Reaction equation

HRID 943014 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[c:10]([CH3:24])[cH:11][c:12](-[n:15]2[n:16][cH:17][c:18]([C:20]([F:21])([F:22])[F:23])[cH:19]2)[cH:13][cH:14]1.[CH2:33]1[O:34][CH2:35][CH2:36][CH2:37]1.[CH3:25][CH2:26][OH:27].[H:28][H:29].[OH-:30].[OH-:32].[Pd+2:31]>>[OH:8][c:9]1[c:10]([CH3:24])[cH:11][c:12](-[n:15]2[n:16][cH:17][c:18]([C:20]([F:21])([F:22])[F:23])[cH:19]2)[cH:13][cH:14]1

Participants

7

Reactant 6

HCID 702EthanolHCID 961Hydroxide2×HCID 8028TetrahydrofuranHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 681565621-(4-(benzyloxy)-3-methylphenyl)-4-(trifluoromethyl)-1H-pyrazoleHCID 178418361HCID 178418361, compound

Product 1

HCID 681562662-methyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenol

Sources & evidence

ORD record
ord-fd99251b267e42e28747451931cea2b2
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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