Dichloromethane → 2-[(4-chloro-benzyl)-pyrrolidin-3-yl-amino]-N-ethyl-acetamide

HRID 943357Notes

Reaction equation

HRID 943357 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH:10]([N:13]([CH2:14][C:15]([NH:16][CH2:17][CH3:18])=[O:19])[CH2:20][c:21]2[cH:22][cH:23][c:24]([Cl:27])[cH:25][cH:26]2)[CH2:11][CH2:12]1)([CH3:5])([CH3:6])[CH3:7].[Cl:35][CH2:36][Cl:37].[OH:28][C:29]([C:30]([F:31])([F:32])[F:33])=[O:34]>>[NH:8]1[CH2:9][CH:10]([N:13]([CH2:14][C:15]([NH:16][CH2:17][CH3:18])=[O:19])[CH2:20][c:21]2[cH:22][cH:23][c:24]([Cl:27])[cH:25][cH:26]2)[CH2:11][CH2:12]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 667587503-[(4-Chloro-benzyl)-ethylcarbamoylmethyl-amino]-pyrrolidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 231370142-[(4-chloro-benzyl)-pyrrolidin-3-yl-amino]-N-ethyl-acetamide

Sources & evidence

ORD record
ord-424c12bf0a8345adb8b2d8e085754665
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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