Acetic Acid → 1-Methyl4-(4-prop-2-ynyl-phenyl)-piperazine

HRID 943526Notes

Reaction equation

HRID 943526 reaction equation
[BH4-:12].[CH3:14][N:15]1[CH2:16][CH2:17][N:18]([c:21]2[cH:22][cH:23][c:24]([CH:27]([C:28]#[CH:29])[OH:30])[cH:25][cH:26]2)[CH2:19][CH2:20]1.[CH3:1][C:2](=[O:3])[OH:4].[Cl:31][CH2:32][Cl:33].[Na+:13].[OH:5][C:6]([C:7]([F:8])([F:9])[F:10])=[O:11]>>[CH3:14][N:15]1[CH2:16][CH2:17][N:18]([c:21]2[cH:22][cH:23][c:24]([CH2:27][C:28]#[CH:29])[cH:25][cH:26]2)[CH2:19][CH2:20]1

Participants

7

Reactant 6

HCID 176Acetic AcidHCID 923Sodium ionHCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 28123BorohydrideHCID 577141411-[4-(4-Methyl-piperazin-1-yl)-phenyl]-prop-2-yn-1-ol

Product 1

HCID 577141261-Methyl4-(4-prop-2-ynyl-phenyl)-piperazine

Sources & evidence

ORD record
ord-4813866457204e0ab965cb24f3a38a0d
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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