Dichloromethane → Trifluoroacetic acid

HRID 943825Notes

Reaction equation

[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([S:14](=[O:15])(=[O:16])[c:17]2[cH:18][cH:19][c:20]([NH:23][c:24]3[n:25][cH:26][c:27]([NH:30][C:31]([c:32]4[c:33]([Cl:51])[cH:34][cH:35][c:36]([NH:38][C:39]([c:40]5[cH:41][c:42]([C:46]([F:47])([F:48])[F:49])[cH:43][cH:44][cH:45]5)=[O:50])[cH:37]4)=[O:52])[cH:28][n:29]3)[cH:21][cH:22]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:60][CH2:61][Cl:62].[F:53][C:54]([C:55](=[O:56])[OH:57])([F:58])[F:59]>>[F:53][C:54]([C:55](=[O:56])[OH:57])([F:58])[F:59].[NH:8]1[CH2:9][CH2:10][CH:11]([S:14](=[O:15])(=[O:16])[c:17]2[cH:18][cH:19][c:20]([NH:23][c:24]3[n:25][cH:26][c:27]([NH:30][C:31]([c:32]4[c:33]([Cl:51])[cH:34][cH:35][c:36]([NH:38][C:39]([c:40]5[cH:41][c:42]([C:46]([F:47])([F:48])[F:49])[cH:43][cH:44][cH:45]5)=[O:50])[cH:37]4)=[O:52])[cH:28][n:29]3)[cH:21][cH:22]2)[CH2:12][CH2:13]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 596527424-(4-{5-[2-Chloro-5-(3-Trifluoromethyl-Benzoylamino)-Benzoylamino]-Pyrimidin-2-ylamino}-Benzenesulfonyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester

Product 2

HCID 6422Trifluoroacetic acid

HCID 249603672-Chloro-N-{2-[4-(Piperidine-4-Sulfonyl)-Phenylamino]-Pyrimidin-5-yl}-5-(3-Trifluoromethyl-Benzoylamino)-Benzamide

Sources & evidence

ORD record: ord-06414755f2514e408ae8074620e6b9d1
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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