Dichloromethane → Trifluoroacetic acid

HRID 943994Notes

Reaction equation

HRID 943994 reaction equation
[C:1]([O:2][C:3](=[O:4])[NH:7][CH:8]([CH2:9][CH2:10][n:11]1[n:12][cH:13][cH:14][n:15]1)[C:16]([NH:17][C:18]1([c:21]2[n:22][cH:23][cH:24][cH:25][n:26]2)[CH2:19][CH2:20]1)=[O:27])([CH3:5])([CH3:6])[CH3:28].[Cl:36][CH2:37][Cl:38].[F:29][C:30]([C:31](=[O:32])[OH:33])([F:34])[F:35]>>[F:29][C:30]([C:31](=[O:32])[OH:33])([F:34])[F:35].[NH2:7][CH:8]([CH2:9][CH2:10][n:11]1[n:12][cH:13][cH:14][n:15]1)[C:16]([NH:17][C:18]1([c:21]2[n:22][cH:23][cH:24][cH:25][n:26]2)[CH2:19][CH2:20]1)=[O:27]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 67390356[1-(1-Pyrimidin-2-yl-cyclopropyl-carbamoyl)-3-1,2,3-triazol-2-yl-propyl]-carbamic acid tert-butyl ester

Product 2

HCID 6422Trifluoroacetic acidHCID 673904572-amino-N-(1-pyrimidin-2-ylcyclopropyl)-4-(triazol-2-yl)butanamide

Sources & evidence

ORD record
ord-dfad8426ffe442f3b8e32302b6c34a4c
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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