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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 944043Generated: October 25, 2026

Water → N-(4-(3-fluoro-7-methoxyquinolin-4-yloxy)phenyl)-4-(4-(trifluoromethyl)phenyl) phthalazin-1-amine

https://huagongshe.com/reaction/944043

Reaction equation

Participants

RoleNameHCIDCharge
ReactantWaterHCID 962—
ReactantTolueneHCID 1140—
ReactantDichloromethaneHCID 6344—
ReactantCarbonate IonHCID 19660—
ReactantPalladiumHCID 23938—
ReactantDibenzylidene acetoneHCID 95417—
ReactantCesium cationHCID 104967—
Reactant4-chloro-3-fluoro-7-methoxyQuinolineHCID 59427320—
Reactant4-(4-(4-(Trifluoromethyl)phenyl)phthalazin-1-ylamino)phenolHCID 136381725—
ProductN-(4-(3-fluoro-7-methoxyquinolin-4-yloxy)phenyl)-4-(4-(trifluoromethyl)phenyl) phthalazin-1-amineHCID 59427330—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetValidation data from https://doi.org/10.1039/C8SC04228D
ORD IDord-bd674ceca76c4ea89305a16a3be328c5
Source noteValidation data from https://doi.org/10.1039/C8SC04228D