Dichloromethane → N-(6-chloro-5-methylpyridin-2-yl)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carboxamide

HRID 944378Notes

Reaction equation

HRID 944378 reaction equation
[CH3:10][CH2:11][N:12]([CH2:13][CH3:14])[CH2:15][CH3:16].[Cl:1][c:2]1[c:3]([CH3:9])[cH:4][cH:5][c:6]([NH2:8])[n:7]1.[Cl:34][CH2:35][Cl:36].[F:17][C:18]1([F:33])[O:19][c:20]2[c:21]([cH:23][cH:24][c:25]([C:27]3([C:30](=[O:31])[Cl:32])[CH2:28][CH2:29]3)[cH:26]2)[O:22]1>>[Cl:1][c:2]1[c:3]([CH3:9])[cH:4][cH:5][c:6]([NH:8][C:30]([C:27]2([c:25]3[cH:24][cH:23][c:21]4[c:20]([cH:26]3)[O:19][C:18]([F:17])([F:33])[O:22]4)[CH2:28][CH2:29]2)=[O:31])[n:7]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 450795946-Chloro-5-methylpyridin-2-amineHCID 575168501-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropanecarbonyl chloride

Product 1

HCID 59165796N-(6-chloro-5-methylpyridin-2-yl)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carboxamide

Sources & evidence

ORD record
ord-d48c7f1c0a3c469799e3819f0f881519
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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