Pyrrolidine → 4-(4-Methylpiperazin-1-yl)-6-[7-(pyrrolidin-1-ylcarbonyl)-3,4-dihydroisoquinolin-2(1H)-yl]pyrimidin-2-amine
Reaction equation
[CH2:28]1[CH2:29][CH2:30][NH:31][CH2:32]1.[NH2:1][c:2]1[n:3][c:4]([N:21]2[CH2:22][CH2:23][N:24]([CH3:27])[CH2:25][CH2:26]2)[cH:5][c:6]([N:8]2[CH2:9][c:10]3[cH:11][c:12]([C:18](=[O:19])[OH:20])[cH:13][cH:14][c:15]3[CH2:16][CH2:17]2)[n:7]1>>[NH2:1][c:2]1[n:3][c:4]([N:21]2[CH2:22][CH2:23][N:24]([CH3:27])[CH2:25][CH2:26]2)[cH:5][c:6]([N:8]2[CH2:9][c:10]3[cH:11][c:12]([C:18](=[O:20])[N:31]4[CH2:30][CH2:29][CH2:28][CH2:32]4)[cH:13][cH:14][c:15]3[CH2:16][CH2:17]2)[n:7]1Participants
3
Sources & evidence
- ORD record
- ord-3a5ad7b9007c41d08c29e989a2ce26c2
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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