Benzene → Methyl 2-chloropyrimidine-5-carboxylate

HRID 944480Notes

Reaction equation

HRID 944480 reaction equation
[CH3:11][Si:12]([CH:13]=[N+:14]=[N-:15])([CH3:16])[CH3:17].[CH3:18][OH:19].[Cl:1][c:2]1[n:3][cH:4][c:5]([C:8](=[O:9])[OH:10])[cH:6][n:7]1.[cH:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1>>[Cl:1][c:2]1[n:3][cH:4][c:5]([C:8]([O:9][CH3:11])=[O:10])[cH:6][n:7]1

Participants

5

Reactant 4

HCID 241BenzeneHCID 887MethanolHCID 167693TrimethylsilyldiazomethaneHCID 110949062-Chloropyrimidine-5-carboxylic acid

Product 1

HCID 12627752Methyl 2-chloropyrimidine-5-carboxylate

Sources & evidence

ORD record
ord-d4d94b4b399844c781a3dcd40236c132
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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