Imidazole → 1-[4-(2-Bromo-ethyl)-piperidin-1-yl]-ethanone

HRID 944618Notes

Reaction equation

HRID 944618 reaction equation
[C:13]([Br:14])([Br:15])([Br:16])[Br:17].[Cl:42][CH2:43][Cl:44].[OH:1][CH2:2][CH2:3][CH:4]1[CH2:5][CH2:6][N:7]([C:10]([CH3:11])=[O:12])[CH2:8][CH2:9]1.[c:18]1([P:19]([c:20]2[cH:21][cH:22][cH:23][cH:24][cH:25]2)[c:26]2[cH:27][cH:28][cH:29][cH:30][cH:31]2)[cH:32][cH:33][cH:34][cH:35][cH:36]1.[nH:37]1[cH:38][cH:39][n:40][cH:41]1>>[CH2:2]([CH2:3][CH:4]1[CH2:5][CH2:6][N:7]([C:10]([CH3:11])=[O:12])[CH2:8][CH2:9]1)[Br:14]

Participants

6

Reactant 5

HCID 795ImidazoleHCID 6344DichloromethaneHCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 21468226Ethanone,1-[4-(2-hydroxyethyl)-1-piperidinyl]-

Product 1

HCID 578501381-[4-(2-Bromo-ethyl)-piperidin-1-yl]-ethanone

Sources & evidence

ORD record
ord-ffe6a7263a5947668410b5475087961d
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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