Dichloromethane → 4-chloro-5-iodo-7-(4-piperidyl)-7H-pyrrolo[2,3-d]pyrimidine

HRID 944667Notes

Reaction equation

HRID 944667 reaction equation
[Cl:1][c:2]1[c:3]2[c:4]([n:5][cH:6][n:7]1)[n:8]([CH:12]1[CH2:13][CH2:14][N:15]([C:18]([O:19][C:20]([CH3:21])([CH3:22])[CH3:23])=[O:24])[CH2:16][CH2:17]1)[cH:9][c:10]2[I:11].[Cl:32][CH2:33][Cl:34].[OH:25][C:26]([C:27]([F:28])([F:29])[F:30])=[O:31]>>[Cl:1][c:2]1[c:3]2[c:4]([n:5][cH:6][n:7]1)[n:8]([CH:12]1[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]1)[cH:9][c:10]2[I:11]

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 22736256tert-butyl 4-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1-piperidinecarboxylate

Product 1

HCID 227362064-chloro-5-iodo-7-(4-piperidyl)-7H-pyrrolo[2,3-d]pyrimidine

Sources & evidence

ORD record
ord-a15a24a3891245de872d2274fd2056ab
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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