5-(4-Fluoro-phenyl)-2-hydroxymethyl-thiazole-4-carboxylic acid → [2-[(5,6-difluoro-1H-benzimidazol-2-yl)methyl]pyrrolidin-1-yl]-[5-(4-fluorophenyl)-2-(hydroxymethyl)-1,3-thiazol-4-yl]methanone
Reaction equation
[F:18][c:19]1[cH:20][cH:21][c:22](-[c:25]2[c:26]([C:32](=[O:33])[OH:34])[n:27][c:28]([CH2:30][OH:31])[s:29]2)[cH:23][cH:24]1.[F:1][c:2]1[cH:3][c:4]2[c:5]([nH:6][c:7]([CH2:9][CH:10]3[NH:11][CH2:12][CH2:13][CH2:14]3)[n:8]2)[cH:15][c:16]1[F:17]>>[F:1][c:2]1[cH:3][c:4]2[c:5]([nH:6][c:7]([CH2:9][CH:10]3[N:11]([C:32]([c:26]4[c:25](-[c:22]5[cH:21][cH:20][c:19]([F:18])[cH:24][cH:23]5)[s:29][c:28]([CH2:30][OH:31])[n:27]4)=[O:33])[CH2:12][CH2:13][CH2:14]3)[n:8]2)[cH:15][c:16]1[F:17]Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-d9787e54e11f4253bee98d929b1e0739
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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