Ammonium → 1-Boc-4-Methylenepiperidine

HRID 944770Notes

Reaction equation

HRID 944770 reaction equation
[Br-:22].[C:1](=[O:2])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])[N:8]1[CH2:9][CH2:10][C:11](=[O:14])[CH2:12][CH2:13]1.[CH3:17][CH2:18][O:19][CH2:20][CH3:21].[CH3:23][P+:24]([c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1)([c:31]1[cH:32][cH:33][cH:34][cH:35][cH:36]1)[c:37]1[cH:38][cH:39][cH:40][cH:41][cH:42]1.[Cl-:15].[NH4+:16]>>[C:1](=[O:2])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])[N:8]1[CH2:9][CH2:10][C:11](=[CH2:17])[CH2:12][CH2:13]1

Participants

7

Reactant 6

HCID 223AmmoniumHCID 259Bromide ionHCID 312ChlorideHCID 3283Diethyl EtherHCID 74506TriphenylmethylphosphoniumHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 27568081-Boc-4-Methylenepiperidine

Sources & evidence

ORD record
ord-808f7564a26046808b56f744b2a28012
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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