Acetate → 2,2,2-trifluoro-N-(4-(6-hydroxyhex-1-yn-1-yl)phenyl)acetamide

HRID 944931Notes

Reaction equation

HRID 944931 reaction equation
[C:27]([O-:28])(=[O:29])[CH3:30].[CH2:15]([CH2:16][CH2:17][CH2:18][C:19]#[CH:20])[OH:21].[CH2:31]([N+:32]([CH2:33][CH2:34][CH2:35][CH3:36])([CH2:37][CH2:38][CH2:39][CH3:40])[CH2:41][CH2:42][CH2:43][CH3:44])[CH2:45][CH2:46][CH3:47].[F:1][C:2]([C:3](=[O:4])[NH:5][c:6]1[cH:7][cH:8][c:9]([I:12])[cH:10][cH:11]1)([F:13])[F:14].[O-:49][C:50]([CH3:51])=[O:52].[O-:53][C:54]([CH3:55])=[O:56].[O:22]=[CH:23][N:24]([CH3:25])[CH3:26].[Pd+2:48]>>[F:1][C:2]([C:3](=[O:4])[NH:5][c:6]1[cH:7][cH:8][c:9]([C:20]#[C:19][CH2:18][CH2:17][CH2:16][CH2:15][OH:21])[cH:10][cH:11]1)([F:13])[F:14]

Participants

7

Reactant 6

HCID 175Acetate3×HCID 6228DimethylformamideHCID 16028TetrabutylammoniumHCID 702345-Hexyn-1-olHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 6869622,2,2-trifluoro-N-(4-iodophenyl)acetamide

Product 1

HCID 575169382,2,2-trifluoro-N-(4-(6-hydroxyhex-1-yn-1-yl)phenyl)acetamide

Sources & evidence

ORD record
ord-0c833ec39ed14dfa9e3e3ad6562947b7
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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