Ethanol → tert-butyl 4-{[4-amino-3-(4-amino-3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl}-4-hydroxy-1-piperidinecarboxylate

HRID 94496Notes

Reaction equation

HRID 94496 reaction equation
[CH3:47][CH2:48][OH:49].[H:45][H:46].[NH2:1][c:2]1[c:3]2[c:4]([n:5][cH:6][n:7]1)[n:8]([CH2:30][C:31]1([OH:44])[CH2:32][CH2:33][N:34]([C:37](=[O:38])[O:39][C:40]([CH3:41])([CH3:42])[CH3:43])[CH2:35][CH2:36]1)[n:9][c:10]2-[c:11]1[cH:12][c:13]([O:28][CH3:29])[c:14]([NH:17][C:18]([O:19][CH2:20][c:21]2[cH:22][cH:23][cH:24][cH:25][cH:26]2)=[O:27])[cH:15][cH:16]1.[O:50]1[CH2:51][CH2:52][CH2:53][CH2:54]1>>[NH2:1][c:2]1[c:3]2[c:4]([n:5][cH:6][n:7]1)[n:8]([CH2:30][C:31]1([OH:44])[CH2:32][CH2:33][N:34]([C:37](=[O:38])[O:39][C:40]([CH3:41])([CH3:42])[CH3:43])[CH2:35][CH2:36]1)[n:9][c:10]2-[c:11]1[cH:12][c:13]([O:28][CH3:29])[c:14]([NH2:17])[cH:15][cH:16]1

Participants

5

Reactant 4

HCID 702EthanolHCID 8028TetrahydrofuranHCID 22346931tert-butyl 4-{[4-amino-3-(4-{[(benzyloxy)carbonyl]amino}-3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl}-4-hydroxy-1-piperidinecarboxylateHCID 178418361HCID 178418361, compound

Product 1

HCID 22347381tert-butyl 4-{[4-amino-3-(4-amino-3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl}-4-hydroxy-1-piperidinecarboxylate

Sources & evidence

ORD record
ord-2bae7bfb50254be59964083c0211156a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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