Tetrahydrofuran → 6-(1-cyclobutylpiperidin-4-yloxy)-3,4-dihydroquinolin-2(1H)-one

HRID 944961Notes

Reaction equation

HRID 944961 reaction equation
[CH:13]1([N:17]2[CH2:18][CH2:19][CH:20]([OH:23])[CH2:21][CH2:22]2)[CH2:14][CH2:15][CH2:16]1.[O:24]1[CH2:25][CH2:26][CH2:27][CH2:28]1.[O:29]=[C:30]([O:31][CH2:32][CH3:33])[N:34]=[N:35][C:36]([O:37][CH2:38][CH3:39])=[O:40].[OH:1][c:2]1[cH:3][c:4]2[c:9]([cH:10][cH:11]1)[NH:8][C:7](=[O:12])[CH2:6][CH2:5]2>>[O:1]([c:2]1[cH:3][c:4]2[c:9]([cH:10][cH:11]1)[NH:8][C:7](=[O:12])[CH2:6][CH2:5]2)[CH:20]1[CH2:19][CH2:18][N:17]([CH:13]2[CH2:14][CH2:15][CH2:16]2)[CH2:22][CH2:21]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 27740406-Hydroxy-3,4-dihydro-2(1H)-quinolinoneHCID 581554161-Cyclobutylpiperidin-4-ol

Product 1

HCID 666826006-(1-cyclobutylpiperidin-4-yloxy)-3,4-dihydroquinolin-2(1H)-one

Sources & evidence

ORD record
ord-831215091cc04e46a2d36f611988aad4
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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