Hydrochloric Acid → 1-(2-Fluoro-4-(trifluoromethyl)phenyl)piperazine

HRID 945064Notes

Reaction equation

HRID 945064 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[c:15]([F:24])[cH:16][c:17]([C:20]([F:21])([F:22])[F:23])[cH:18][cH:19]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[ClH:25].[O:26]1[CH2:27][CH2:28][O:29][CH2:30][CH2:31]1>>[NH:8]1[CH2:9][CH2:10][N:11]([c:14]2[c:15]([F:24])[cH:16][c:17]([C:20]([F:21])([F:22])[F:23])[cH:18][cH:19]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 534855174-(2-Fluoro-4-trifluoromethylphenyl)piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 468374951-(2-Fluoro-4-(trifluoromethyl)phenyl)piperazine

Sources & evidence

ORD record
ord-4a5ae09fa5e54685adec77d8ba7c2d02
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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