Tetrahydrofuran → [4-Benzyl-3-(4-fluorophenyl)morpholin-2-yl] 3,5-bis(trifluoromethyl)benzoate

HRID 945537Notes

Reaction equation

HRID 945537 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH:9]([c:15]2[cH:16][cH:17][c:18]([F:21])[cH:19][cH:20]2)[C:10](=[O:14])[O:11][CH2:12][CH2:13]1.[CH2:39]1[O:40][CH2:41][CH2:42][CH2:43]1.[F:22][C:23]([c:24]1[cH:25][c:26]([C:27](=[O:28])[Cl:29])[cH:30][c:31]([C:33]([F:34])([F:35])[F:36])[cH:32]1)([F:37])[F:38]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH:9]([c:15]2[cH:16][cH:17][c:18]([F:21])[cH:19][cH:20]2)[CH:10]([O:14][C:27]([c:26]2[cH:25][c:24]([C:23]([F:22])([F:37])[F:38])[cH:32][c:31]([C:33]([F:34])([F:35])[F:36])[cH:30]2)=[O:28])[O:11][CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 1018563,5-Bis(trifluoromethyl)benzoyl chlorideHCID 98823013-(4-Fluorophenyl)-4-(phenylmethyl)-2-morpholinone

Product 1

HCID 18004688[4-Benzyl-3-(4-fluorophenyl)morpholin-2-yl] 3,5-bis(trifluoromethyl)benzoate

Sources & evidence

ORD record
ord-ade1ab1e1b4d4788bc61b3e82e01c6bf
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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