Sodium ion → 4-[5-(3-Bromo-4-cyclohexyloxy-phenyl)-6-butyl-pyridazin-3-yloxy]-piperidine-1-carboxylic acid tert-butyl ester

HRID 945747Notes

Reaction equation

HRID 945747 reaction equation
[Br:17][c:18]1[cH:19][c:20](-[c:31]2[c:32]([CH2:38][CH2:39][CH2:40][CH3:41])[n:33][n:34][c:35]([Cl:37])[cH:36]2)[cH:21][cH:22][c:23]1[O:24][CH:25]1[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]1.[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([OH:14])[CH2:12][CH2:13]1.[CH2:43]1[O:44][CH2:45][CH2:46][CH2:47]1.[H-:16].[Na+:15].[OH2:42]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([O:14][c:35]2[n:34][n:33][c:32]([CH2:38][CH2:39][CH2:40][CH3:41])[c:31](-[c:20]3[cH:19][c:18]([Br:17])[c:23]([O:24][CH:25]4[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]4)[cH:22][cH:21]3)[cH:36]2)[CH2:12][CH2:13]1

Participants

7

Reactant 6

HCID 923Sodium ionHCID 962WaterHCID 8028TetrahydrofuranHCID 166653HydrideHCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylateHCID 866578204-(3-Bromo-4-cyclohexyloxy-phenyl)-3-butyl-6-chloro-pyridazine

Product 1

HCID 673737524-[5-(3-Bromo-4-cyclohexyloxy-phenyl)-6-butyl-pyridazin-3-yloxy]-piperidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-8259aa6ed9ee4f529213929106dd05e2
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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