Hydrochloric Acid → 2-Fluoro-4-(piperazin-1-YL)benzonitrile

HRID 945776Notes

Reaction equation

HRID 945776 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[cH:15][c:16]([F:22])[c:17]([C:20]#[N:21])[cH:18][cH:19]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[CH3:24][OH:25].[ClH:23]>>[NH:8]1[CH2:9][CH2:10][N:11]([c:14]2[cH:15][c:16]([F:22])[c:17]([C:20]#[N:21])[cH:18][cH:19]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 54552536Tert-butyl 4-(4-cyano-3-fluorophenyl)piperazine-1-carboxylate

Product 1

HCID 187600452-Fluoro-4-(piperazin-1-YL)benzonitrile

Sources & evidence

ORD record
ord-ca7a9a1f816147d29dda9025776dd404
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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