1-(6-Benzyl-3-nitroquinolin-4-ylamino)-2-methylpropan-2-ol → HCID 21984192, compound

HRID 9459Notes

Reaction equation

HRID 9459 reaction equation
[CH2:1]([C:8]1[CH:17]=[C:16]2[C:11]([C:12]([NH:21][CH2:22][C:23]([CH3:26])([OH:25])[CH3:24])=[C:13]([N+:18]([O-])=O)[CH:14]=[N:15]2)=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:27]([C:34]1[CH:35]=[C:36]2[C:41](=[CH:42][CH:43]=1)[N:40]=[CH:39][C:38]([N+:44]([O-])=O)=[C:37]2[NH:47][CH2:48][C:49]([CH3:52])([OH:51])[CH3:50])[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>>[NH2:18][C:13]1[CH:14]=[N:15][C:16]2[C:11]([C:12]=1[NH:21][CH2:22][C:23]([CH3:26])([OH:25])[CH3:24])=[CH:10][CH:9]=[C:8]([CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[CH:17]=2.[NH2:44][C:38]1[CH:39]=[N:40][C:41]2[C:36]([C:37]=1[NH:47][CH2:48][C:49]([CH3:52])([OH:51])[CH3:50])=[CH:35][C:34]([CH2:27][C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1)=[CH:43][CH:42]=2

Participants

4

Reactant 2

HCID 219844101-(6-Benzyl-3-nitroquinolin-4-ylamino)-2-methylpropan-2-olHCID 219844521-(7-Benzyl-3-nitroquinolin-4-ylamino)-2-methylpropan-2-ol

Product 2

HCID 21984192HCID 21984192, compoundHCID 219843621-(3-Amino-6-benzylquinolin-4-ylamino)-2-methylpropan-2-ol

Procedure

A modification of the method described in Part A of Examples 427–429 was used to reduce 1-(7-benzyl-3-nitroquinolin-4-ylamino)-2-methylpropan-2-ol or 1-(6-benzyl-3-nitroquinolin-4-ylamino)-2-methylpropan-2-ol. The reaction was shaken for one or two days to provide 1-(3-amino-7-benzylquinolin-4-ylamino)-2-methylpropan-2-ol or 1-(3-amino-6-benzylquinolin-4-ylamino)-2-methylpropan-2-ol.

Sources & evidence

ORD record
ord-8dca345f64d74c3baa164565dcda69f8
Source dataset
uspto-grants-2006_08
Patent number
US07091214B2

Reaction notes

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