Tetrahydrofuran → 3',5'-Bis(trifluoromethyl)-2-aminobenzophenone

HRID 945917Notes

Reaction equation

HRID 945917 reaction equation
[CH2:29]([Li:30])[CH2:31][CH2:32][CH3:33].[CH3:1][O:2][N:3]([C:4]([c:5]1[c:6]([NH2:7])[cH:8][cH:9][cH:10][cH:11]1)=[O:12])[CH3:13].[F:14][C:15]([c:16]1[cH:17][c:18]([Br:26])[cH:19][c:20]([C:22]([F:23])([F:24])[F:25])[cH:21]1)([F:27])[F:28].[O:34]1[CH2:35][CH2:36][CH2:37][CH2:38]1>>[C:4]([c:5]1[c:6]([NH2:7])[cH:8][cH:9][cH:10][cH:11]1)(=[O:12])[c:18]1[cH:17][c:16]([C:15]([F:14])([F:27])[F:28])[cH:21][c:20]([C:22]([F:23])([F:24])[F:25])[cH:19]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 676021-Bromo-3,5-bis(trifluoromethyl)benzeneHCID 110522422-amino-N-methoxy-N-methylbenzamideHCID 178418339Butyllithium

Product 1

HCID 866513633',5'-Bis(trifluoromethyl)-2-aminobenzophenone

Sources & evidence

ORD record
ord-8681cc5e10784ce8a5721e661d366412
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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