Dichloromethane → Methyl 4-[(4-methoxypyrrolidine-2-carbonyl)amino]benzoate

HRID 945976Notes

Reaction equation

HRID 945976 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH:9]([C:15]([NH:16][c:17]2[cH:18][cH:19][c:20]([C:23](=[O:24])[O:25][CH3:26])[cH:21][cH:22]2)=[O:27])[CH2:10][CH:11]([O:13][CH3:14])[CH2:12]1)([CH3:5])([CH3:6])[CH3:7].[Cl:35][CH2:36][Cl:37].[F:28][C:29]([F:30])([F:31])[C:32]([OH:33])=[O:34]>>[NH:8]1[CH:9]([C:15]([NH:16][c:17]2[cH:18][cH:19][c:20]([C:23](=[O:24])[O:25][CH3:26])[cH:21][cH:22]2)=[O:27])[CH2:10][CH:11]([O:13][CH3:14])[CH2:12]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 69176808Tert-butyl 4-methoxy-2-[(4-methoxycarbonylphenyl)carbamoyl]pyrrolidine-1-carboxylate

Product 1

HCID 61260727Methyl 4-[(4-methoxypyrrolidine-2-carbonyl)amino]benzoate

Sources & evidence

ORD record
ord-d14693d11b85416e9d665e213bc09350
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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