Hydrochloric Acid → (1-{4-[3-(4-Chloro-3-(trifluoromethyl)phenyl)-3-hydroxyureido]phenyl}-1H-indol-5-yl)carbamic acid ethyl ester

HRID 946139Notes

Reaction equation

HRID 946139 reaction equation
[Cl:34][C:35](=[O:36])[O:37][CH2:38][CH3:39].[ClH:1].[NH2:2][c:3]1[cH:4][c:5]2[cH:6][cH:7][n:8](-[c:12]3[cH:13][cH:14][c:15]([NH:18][C:19](=[O:20])[N:21]([OH:22])[c:23]4[cH:24][c:25]([C:30]([F:31])([F:32])[F:33])[c:26]([Cl:29])[cH:27][cH:28]4)[cH:16][cH:17]3)[c:9]2[cH:10][cH:11]1>>[NH:2]([c:3]1[cH:4][c:5]2[cH:6][cH:7][n:8](-[c:12]3[cH:13][cH:14][c:15]([NH:18][C:19](=[O:20])[N:21]([OH:22])[c:23]4[cH:24][c:25]([C:30]([F:31])([F:32])[F:33])[c:26]([Cl:29])[cH:27][cH:28]4)[cH:16][cH:17]3)[c:9]2[cH:10][cH:11]1)[C:35](=[O:36])[O:37][CH2:38][CH3:39]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 10928Ethyl chloroformateHCID 231550473-[4-(5-Aminoindol-1-yl)phenyl]-1-[4-chloro-3-(trifluoromethyl)phenyl]-1-hydroxyurea

Product 1

HCID 59725947(1-{4-[3-(4-Chloro-3-(trifluoromethyl)phenyl)-3-hydroxyureido]phenyl}-1H-indol-5-yl)carbamic acid ethyl ester

Sources & evidence

ORD record
ord-5d715ff86edd4315af7eb7c38d649ac3
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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