Water → 2,5-Difluoro-3-fluoromethyl-4-(4-ethoxycarbonyl-1-piperazinyl)nitrobenzene

HRID 946163Notes

Reaction equation

HRID 946163 reaction equation
[CH2:25]([N:26]([S:27]([F:28])([F:29])[F:31])[CH2:30][CH3:32])[CH3:33].[CH3:34][CH2:35][N:36]([CH2:37][CH3:38])[CH2:39][CH3:40].[Cl:42][CH2:43][Cl:44].[F:1][c:2]1[c:3]([N:14]2[CH2:15][CH2:16][N:17]([C:20](=[O:21])[O:22][CH2:23][CH3:24])[CH2:18][CH2:19]2)[c:4]([CH2:5][OH:6])[c:7]([F:13])[c:8]([N+:10](=[O:11])[O-:12])[cH:9]1.[OH2:41]>>[F:1][c:2]1[c:3]([N:14]2[CH2:15][CH2:16][N:17]([C:20](=[O:21])[O:22][CH2:23][CH3:24])[CH2:18][CH2:19]2)[c:4]([CH2:5][F:31])[c:7]([F:13])[c:8]([N+:10](=[O:11])[O-:12])[cH:9]1

Participants

6

Reactant 5

HCID 962WaterHCID 6344DichloromethaneHCID 8471TriethylamineHCID 123472(Diethylamino)sulfur trifluorideHCID 156225283,6-Difluoro-2-(4-ethoxycarbonyl-1-piperazinyl)-5-nitrobenzyl alcohol

Product 1

HCID 198411452,5-Difluoro-3-fluoromethyl-4-(4-ethoxycarbonyl-1-piperazinyl)nitrobenzene

Sources & evidence

ORD record
ord-3b83f87195db4ace854dc1332f250917
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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