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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 946201Generated: October 26, 2026

Water → 2-Amino-5-[4-(difluoromethoxy)phenyl]-5-[3-(5-hydroxypent-1-yn-1-yl)phenyl]-3-methyl-3,5-dihydro-4H-imidazol-4-one

https://huagongshe.com/reaction/946201

Reaction equation

Participants

RoleNameHCIDCharge
ReactantWaterHCID 962—
ReactantDiisopropylamineHCID 7912—
Reactant1,4-DioxaneHCID 31275—
Reactant4-Pentyn-1-olHCID 79346—
ReactantTris(1,1-dimethylethyl)phosphineHCID 83681—
Reactant2-amino-4-(3-bromophenyl)-4-(4-(difluoromethoxy)phenyl)-1-methyl-1H-imidazol-5(4H)-oneHCID 59790307—
Product2-Amino-5-[4-(difluoromethoxy)phenyl]-5-[3-(5-hydroxypent-1-yn-1-yl)phenyl]-3-methyl-3,5-dihydro-4H-imidazol-4-oneHCID 59790323—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetValidation data from https://doi.org/10.1039/C8SC04228D
ORD IDord-39a14ce89a644897a84632dfc5ab4d52
Source noteValidation data from https://doi.org/10.1039/C8SC04228D