Water → 2-Amino-5-[4-(difluoromethoxy)phenyl]-5-[3-(5-hydroxypent-1-yn-1-yl)phenyl]-3-methyl-3,5-dihydro-4H-imidazol-4-one

HRID 946201Notes

Reaction equation

HRID 946201 reaction equation
[C:26]([P:27]([C:28]([CH3:29])([CH3:30])[CH3:31])[C:32]([CH3:33])([CH3:34])[CH3:35])([CH3:36])([CH3:37])[CH3:38].[CH2:46]([CH2:47][CH2:48][C:49]#[CH:50])[OH:51].[CH:39]([NH:40][CH:41]([CH3:42])[CH3:43])([CH3:44])[CH3:45].[NH2:1][C:2]1=[N:3][C:4]([c:9]2[cH:10][cH:11][c:12]([O:15][CH:16]([F:17])[F:18])[cH:13][cH:14]2)([c:19]2[cH:20][c:21]([Br:25])[cH:22][cH:23][cH:24]2)[C:5](=[O:8])[N:6]1[CH3:7].[O:53]1[CH2:54][CH2:55][O:56][CH2:57][CH2:58]1.[OH2:52]>>[NH2:1][C:2]1=[N:3][C:4]([c:9]2[cH:10][cH:11][c:12]([O:15][CH:16]([F:17])[F:18])[cH:13][cH:14]2)([c:19]2[cH:20][c:21]([C:50]#[C:49][CH2:48][CH2:47][CH2:46][OH:51])[cH:22][cH:23][cH:24]2)[C:5](=[O:8])[N:6]1[CH3:7]

Participants

7

Reactant 6

HCID 962WaterHCID 7912DiisopropylamineHCID 312751,4-DioxaneHCID 793464-Pentyn-1-olHCID 83681Tris(1,1-dimethylethyl)phosphineHCID 597903072-amino-4-(3-bromophenyl)-4-(4-(difluoromethoxy)phenyl)-1-methyl-1H-imidazol-5(4H)-one

Product 1

HCID 597903232-Amino-5-[4-(difluoromethoxy)phenyl]-5-[3-(5-hydroxypent-1-yn-1-yl)phenyl]-3-methyl-3,5-dihydro-4H-imidazol-4-one

Sources & evidence

ORD record
ord-39a14ce89a644897a84632dfc5ab4d52
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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