Acetic Acid → N-{1-[6-(5-Bromo-1-methyl-2-oxo-1,2-dihydro-pyridin-3-ylamino)-pyridin-3-yl]-1-methyl-ethyl}-2-chloro-acetamide

HRID 946348Notes

Reaction equation

HRID 946348 reaction equation
[Br:1][c:2]1[cH:3][c:4]([NH:10][c:11]2[n:12][cH:13][c:14]([C:17]([CH3:18])([CH3:19])[OH:20])[cH:15][cH:16]2)[c:5](=[O:9])[n:6]([CH3:8])[cH:7]1.[C:30](=[O:31])([OH:32])[O-:33].[CH3:21][C:22]([OH:23])=[O:24].[CH3:39][CH2:40][O:41][C:42](=[O:43])[CH3:44].[Cl:35][CH2:36][C:37]#[N:38].[Na+:34].[S:25](=[O:26])(=[O:27])([OH:28])[OH:29]>>[Br:1][c:2]1[cH:3][c:4]([NH:10][c:11]2[n:12][cH:13][c:14]([C:17]([CH3:18])([CH3:19])[NH:38][C:37](=[O:23])[CH2:36][Cl:35])[cH:15][cH:16]2)[c:5](=[O:9])[n:6]([CH3:8])[cH:7]1

Participants

8

Reactant 7

HCID 176Acetic AcidHCID 769Bicarbonate IonHCID 923Sodium ionHCID 1118Sulfuric AcidHCID 7856ChloroacetonitrileHCID 8857Ethyl AcetateHCID 594737935-Bromo-3-[5-(1-hydroxy-1-methyl-ethyl)-pyridin-2-ylamino]-1-methyl-1H-pyridin-2-one

Product 1

HCID 59473779N-{1-[6-(5-Bromo-1-methyl-2-oxo-1,2-dihydro-pyridin-3-ylamino)-pyridin-3-yl]-1-methyl-ethyl}-2-chloro-acetamide

Sources & evidence

ORD record
ord-404cb4d656ef4ba8b8b0b620dc2d8d96
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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