反应详情

(7-Bromo-3-nitroquinolin-4-yl)-(2-methylpropyl)amine (117 g) was dissolved in hot toluene (2 L) and poured into stainless steel Parr vessel. Additional toluene (2 L) and 5% platinum on carbon (12.5 g) were added. The vessel was evacuated, charged with hydrogen (54 psi, 3.7×105 Pa), and shaken overnight at room temperature. The reaction mixture evacuated, filtered through a layer of CELITE filter aid, and concentrated under reduced pressure to provide 7-bromo-N4-(2-methylpropyl)quinoline-3,4-diamine, which was used without purification.

1. customThe vessel was evacuated
2. additioncharged with hydrogen (54 psi, 3.7×105 Pa)
3. customThe reaction mixture evacuated
4. filtrationfiltered through a layer of CELITE
5. filtrationfilter aid
6. concentrationconcentrated under reduced pressure