Potassium Cation → tert-butyl 4-(4-chloro-2-formylphenyl)tetrahydro-1(2H)-pyrazinecarboxylate

HRID 946758Notes

Reaction equation

HRID 946758 reaction equation
[C:11]([CH3:12])([CH3:13])([CH3:14])[O:15][C:16](=[O:17])[N:18]1[CH2:19][CH2:20][NH:21][CH2:22][CH2:23]1.[Cl:1][c:2]1[cH:3][cH:4][c:5]([F:10])[c:6]([CH:7]=[O:8])[cH:9]1.[K+:24].[K+:25].[O-:26][C:27]([O-:28])=[O:29].[O:31]=[CH:32][N:33]([CH3:34])[CH3:35].[OH2:30]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([N:21]2[CH2:20][CH2:19][N:18]([C:16]([O:15][C:11]([CH3:12])([CH3:13])[CH3:14])=[O:17])[CH2:23][CH2:22]2)[c:6]([CH:7]=[O:8])[cH:9]1

Participants

7

Reactant 6

HCID 813Potassium Cation2×HCID 962WaterHCID 6228DimethylformamideHCID 19660Carbonate IonHCID 143452tert-Butyl piperazine-1-carboxylateHCID 27735865-Chloro-2-fluorobenzaldehyde

Product 1

HCID 11529912tert-butyl 4-(4-chloro-2-formylphenyl)tetrahydro-1(2H)-pyrazinecarboxylate

Sources & evidence

ORD record
ord-735c55f983ce40f4b6119a7ee2e43afa
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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