Sodium ion → Tert-butyl 3-[1-[2-[tert-butyl(dimethyl)silyl]oxyethoxy]-1-(3-chlorophenyl)ethyl]piperidine-1-carboxylate

HRID 947323Notes

Reaction equation

HRID 947323 reaction equation
[Br:26][CH2:27][CH2:28][O:29][Si:30]([CH3:31])([CH3:32])[C:33]([CH3:34])([CH3:35])[CH3:36].[CH2:37]1[O:38][CH2:39][CH2:40][CH2:41]1.[Cl:1][c:2]1[cH:3][c:4]([C:8]([CH3:9])([OH:10])[CH:11]2[CH2:12][N:13]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[CH2:14][CH2:15][CH2:16]2)[cH:5][cH:6][cH:7]1.[H-:25].[Na+:24]>>[Cl:1][c:2]1[cH:3][c:4]([C:8]([CH3:9])([O:10][CH2:27][CH2:28][O:29][Si:30]([CH3:31])([CH3:32])[C:33]([CH3:34])([CH3:35])[CH3:36])[CH:11]2[CH2:12][N:13]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[CH2:14][CH2:15][CH2:16]2)[cH:5][cH:6][cH:7]1

Participants

6

Reactant 5

HCID 923Sodium ionHCID 8028TetrahydrofuranHCID 166653HydrideHCID 3608067(2-Bromoethoxy)-tert-butyldimethylsilaneHCID 72529661Tert-butyl 3-[1-(3-chlorophenyl)-1-hydroxyethyl]piperidine-1-carboxylate

Product 1

HCID 72529628Tert-butyl 3-[1-[2-[tert-butyl(dimethyl)silyl]oxyethoxy]-1-(3-chlorophenyl)ethyl]piperidine-1-carboxylate

Sources & evidence

ORD record
ord-f3536eb76d8a4ddbaabedbac195da563
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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