Toluene → Rivaroxaban, Xarelto, BAY 59-7939
Reaction equation
[CH3:28][N:29]1[C:30](=[O:34])[CH2:33][CH2:32][CH2:31]1.[CH3:35][c:36]1[cH:37][cH:38][cH:39][cH:40][cH:41]1.[OH:1][CH:2]([CH2:3][NH:4][C:5](=[O:6])[c:7]1[s:8][c:9]([Cl:12])[cH:10][cH:11]1)[CH2:13][NH:14][c:15]1[cH:16][cH:17][c:18]([N:21]2[C:22](=[O:27])[CH2:23][O:24][CH2:25][CH2:26]2)[cH:19][cH:20]1>>[O:1]1[CH:2]([CH2:3][NH:4][C:5](=[O:6])[c:7]2[s:8][c:9]([Cl:12])[cH:10][cH:11]2)[CH2:13][N:14]([c:15]2[cH:16][cH:17][c:18]([N:21]3[C:22](=[O:27])[CH2:23][O:24][CH2:25][CH2:26]3)[cH:19][cH:20]2)[C:30]1=[O:34]Participants
4
Sources & evidence
- ORD record
- ord-f6ea91142f194c5a84bbf20b649ec126
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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