Hydrochloric Acid → 2-(1-Aminobut-3-ynyl)-3-anilino-7-chloroquinazolin-4-one

HRID 947588Notes

Reaction equation

HRID 947588 reaction equation
[C:1]([O:2][C:3](=[O:4])[NH:7][CH:8]([CH2:9][C:10]#[CH:11])[c:12]1[n:13][c:14]2[cH:15][c:16]([Cl:30])[cH:17][cH:18][c:19]2[c:20](=[O:29])[n:21]1[NH:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1)([CH3:5])([CH3:6])[CH3:31].[CH3:33][OH:34].[ClH:32].[O:35]1[CH2:36][CH2:37][O:38][CH2:39][CH2:40]1>>[NH2:7][CH:8]([CH2:9][C:10]#[CH:11])[c:12]1[n:13][c:14]2[cH:15][c:16]([Cl:30])[cH:17][cH:18][c:19]2[c:20](=[O:29])[n:21]1[NH:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 312751,4-DioxaneHCID 76595877tert-butyl N-[1-(3-anilino-7-chloro-4-oxoquinazolin-2-yl)but-3-ynyl]carbamate

Product 1

HCID 765529352-(1-Aminobut-3-ynyl)-3-anilino-7-chloroquinazolin-4-one

Sources & evidence

ORD record
ord-35e1a49dd49b4b32a110ba1eb1268824
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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