Methane → 4-(4-Fluoro-benzyl)-piperidine-1-carboxylic acid tert-butyl ester

HRID 947649Notes

Reaction equation

HRID 947649 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11](=[CH:14][c:15]2[cH:16][cH:17][c:18]([F:21])[cH:19][cH:20]2)[CH2:12][CH2:13]1.[C:24].[CH3:22][OH:23].[Pd:25]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([CH2:14][c:15]2[cH:16][cH:17][c:18]([F:21])[cH:19][cH:20]2)[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 297MethaneHCID 887MethanolHCID 23938PalladiumHCID 22676694N-t-butoxycarbonyl-4-(4-fluorobenzylidene)piperidine

Product 1

HCID 226766794-(4-Fluoro-benzyl)-piperidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-baacd534bd564450951b997a7c05c799
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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