Sodium ion → 4-Methyl-2-thiazol-2-yl-pyrimidine-5-carboxylic acid (3-ethyl-5-trifluoromethyl-indol-1-yl)-amide

HRID 947712Notes

Reaction equation

HRID 947712 reaction equation
[C:37](=[O:38])([O-:39])[O-:40].[CH2:16]([CH3:17])[c:18]1[cH:19][n:20]([NH2:31])[c:21]2[cH:22][cH:23][c:24]([C:27]([F:28])([F:29])[F:30])[cH:25][c:26]12.[CH3:1][c:2]1[n:3][c:4](-[c:11]2[s:12][cH:13][cH:14][n:15]2)[n:5][cH:6][c:7]1[C:8](=[O:9])[OH:10].[Na+:41].[Na+:42].[O:32]=[CH:33][N:34]([CH3:35])[CH3:36]>>[CH3:1][c:2]1[n:3][c:4](-[c:11]2[s:12][cH:13][cH:14][n:15]2)[n:5][cH:6][c:7]1[C:8](=[O:10])[NH:31][n:20]1[cH:19][c:18]([CH2:16][CH3:17])[c:26]2[c:21]1[cH:22][cH:23][c:24]([C:27]([F:28])([F:29])[F:30])[cH:25]2

Participants

6

Reactant 5

HCID 923Sodium ion2×HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 685536304-methyl-2-(2-thiazolyl)-5-Pyrimidinecarboxylic acidHCID 685542413-Ethyl-5-trifluoromethyl-indol-1-ylamine

Product 1

HCID 592000094-Methyl-2-thiazol-2-yl-pyrimidine-5-carboxylic acid (3-ethyl-5-trifluoromethyl-indol-1-yl)-amide

Sources & evidence

ORD record
ord-f927ebb20e024b33b74f4d8d813edb17
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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