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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 947788Generated: October 30, 2026

Tetrahydrofuran → [2-Fluoro-4-(2,2,4,4-tetramethyl-chroman-6-ylethynyl) phenyl]acetic acid ethyl ester

https://huagongshe.com/reaction/947788

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTetrahydrofuranHCID 8028—
ReactantHexaneHCID 8058—
ReactantTriethylamineHCID 8471—
ReactantEthyl AcetateHCID 8857—
ReactantTriphenylphosphineHCID 11776—
ReactantPalladium ChlorideHCID 24290—
ReactantCopper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 24350—
Reactant2,2,4,4-Tetramethyl-6-ethynylchromanHCID 15661138—
ReactantEthyl 2-fluoro-4-iodophenylacetateHCID 18740710—
Product[2-Fluoro-4-(2,2,4,4-tetramethyl-chroman-6-ylethynyl) phenyl]acetic acid ethyl esterHCID 69548829—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetValidation data from https://doi.org/10.1039/C8SC04228D
ORD IDord-08a67d58d5664c079e269152d1c6e8b3
Source noteValidation data from https://doi.org/10.1039/C8SC04228D