Tetrahydrofuran → [2-Fluoro-4-(2,2,4,4-tetramethyl-chroman-6-ylethynyl) phenyl]acetic acid ethyl ester

HRID 947788Notes

Reaction equation

[C:1](#[CH:2])[c:3]1[cH:4][c:5]2[c:10]([cH:11][cH:12]1)[O:9][C:8]([CH3:13])([CH3:14])[CH2:7][C:6]2([CH3:15])[CH3:16].[CH2:17]([CH3:18])[O:19][C:20]([CH2:21][c:22]1[c:23]([F:29])[cH:24][c:25]([I:28])[cH:26][cH:27]1)=[O:30].[CH2:31]([N:32]([CH2:33][CH3:34])[CH2:35][CH3:36])[CH3:37].[CH3:43][CH2:44][CH2:45][CH2:46][CH2:47][CH3:48].[CH3:92][CH2:93][O:94][C:95](=[O:96])[CH3:97].[Cu:49][I:50].[O:38]1[CH2:39][CH2:40][CH2:41][CH2:42]1.[Pd:51]([Cl:52])[Cl:53].[c:54]1([P:55]([c:56]2[cH:57][cH:58][cH:59][cH:60][cH:61]2)[c:62]2[cH:63][cH:64][cH:65][cH:66][cH:67]2)[cH:68][cH:69][cH:70][cH:71][cH:72]1.[c:73]1([P:74]([c:75]2[cH:76][cH:77][cH:78][cH:79][cH:80]2)[c:81]2[cH:82][cH:83][cH:84][cH:85][cH:86]2)[cH:87][cH:88][cH:89][cH:90][cH:91]1>>[C:1](#[C:2][c:25]1[cH:24][c:23]([F:29])[c:22]([CH2:21][C:20]([O:19][CH2:17][CH3:18])=[O:30])[cH:27][cH:26]1)[c:3]1[cH:4][c:5]2[c:10]([cH:11][cH:12]1)[O:9][C:8]([CH3:13])([CH3:14])[CH2:7][C:6]2([CH3:15])[CH3:16]