Dimethyl Sulfoxide → Tert-butyl 4-(3-hydroxypyrrolidin-1-yl)benzoate

HRID 948255Notes

Reaction equation

HRID 948255 reaction equation
[C:21](=[O:22])([O-:23])[O-:24].[CH3:27][S:28]([CH3:29])=[O:30].[CH3:31][CH2:32][O:33][C:34]([CH3:35])=[O:36].[F:1][c:2]1[cH:3][cH:4][c:5]([C:6](=[O:7])[O:8][C:9]([CH3:10])([CH3:11])[CH3:12])[cH:13][cH:14]1.[K+:25].[K+:26].[NH:15]1[CH2:16][CH:17]([OH:20])[CH2:18][CH2:19]1>>[c:2]1([N:15]2[CH2:16][CH:17]([OH:20])[CH2:18][CH2:19]2)[cH:3][cH:4][c:5]([C:6](=[O:7])[O:8][C:9]([CH3:10])([CH3:11])[CH3:12])[cH:13][cH:14]1

Participants

7

Reactant 6

HCID 679Dimethyl SulfoxideHCID 813Potassium Cation2×HCID 8857Ethyl AcetateHCID 19660Carbonate IonHCID 982104-HydroxypyrrolidineHCID 2736444Tert-butyl 4-fluorobenzoate

Product 1

HCID 10084125Tert-butyl 4-(3-hydroxypyrrolidin-1-yl)benzoate

Sources & evidence

ORD record
ord-59e8dec992b946f29207bbedcee00aa4
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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