Dichloromethane → Tert-butyl 4-(methylsulfonyl)piperidine-1-carboxylate

HRID 948932Notes

Reaction equation

HRID 948932 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([OH:14])[CH2:12][CH2:13]1.[CH3:15][S:16]([Cl:17])(=[O:18])=[O:19].[CH3:20][CH2:21][N:22]([CH2:23][CH3:24])[CH2:25][CH3:26].[Cl:27][CH2:28][Cl:29]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([S:16]([CH3:15])(=[O:18])=[O:19])[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylate

Product 1

HCID 22504298Tert-butyl 4-(methylsulfonyl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-39ba715a29fe4e91bbe54b473282e6f2
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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