Acetic Acid → Ethyl (3-chloro-4-{1,3-dioxo-4,9-bis[(phenylmethyl)oxy]-1,3-dihydro-2H-benzo[f]isoindol-2-yl}phenyl)acetate

HRID 949261Notes

Reaction equation

HRID 949261 reaction equation
[CH3:48][N:49]([c:50]1[cH:51][cH:52][n:53][cH:54][cH:55]1)[CH3:56].[CH3:57][C:58](=[O:59])[OH:60].[NH2:33][c:34]1[c:35]([Cl:46])[cH:36][c:37]([CH2:40][C:41](=[O:42])[O:43][CH2:44][CH3:45])[cH:38][cH:39]1.[OH2:47].[c:1]1([CH2:7][O:8][c:9]2[c:10]([C:30](=[O:31])[OH:32])[c:11]([C:27](=[O:28])[OH:29])[c:12]([O:19][CH2:20][c:21]3[cH:22][cH:23][cH:24][cH:25][cH:26]3)[c:13]3[cH:14][cH:15][cH:16][cH:17][c:18]23)[cH:2][cH:3][cH:4][cH:5][cH:6]1>>[c:1]1([CH2:7][O:8][c:9]2[c:10]3[c:11]([c:12]([O:19][CH2:20][c:21]4[cH:22][cH:23][cH:24][cH:25][cH:26]4)[c:13]4[cH:14][cH:15][cH:16][cH:17][c:18]24)[C:27](=[O:28])[N:33]([c:34]2[c:35]([Cl:46])[cH:36][c:37]([CH2:40][C:41](=[O:42])[O:43][CH2:44][CH3:45])[cH:38][cH:39]2)[C:30]3=[O:31])[cH:2][cH:3][cH:4][cH:5][cH:6]1

Participants

6

Reactant 5

HCID 176Acetic AcidHCID 962WaterHCID 142844-(Dimethylamino)pyridineHCID 4380201,4-Bis[(phenylmethyl)oxy]-2,3-naphthalenedicarboxylic acidHCID 17859298(4-Amino-3-chloro-phenyl)-acetic acid ethyl ester

Product 1

HCID 58012507Ethyl (3-chloro-4-{1,3-dioxo-4,9-bis[(phenylmethyl)oxy]-1,3-dihydro-2H-benzo[f]isoindol-2-yl}phenyl)acetate

Sources & evidence

ORD record
ord-7d582ee65731401abfd1081a0d50c6e0
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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