Triphenylphosphine → 3-Fluoro-4-(2-(furan-2-yl)thieno[3,2-b]pyridin-7-yloxy)benzenamine

HRID 94936Notes

Reaction equation

HRID 94936 reaction equation
[CH2:20]([Sn:21]([CH2:22][CH2:23][CH2:24][CH3:30])([c:25]1[o:26][cH:27][cH:28][cH:29]1)[CH2:31][CH2:32][CH2:33][CH3:34])[CH2:35][CH2:36][CH3:37].[F:1][c:2]1[cH:3][c:4]([NH2:5])[cH:6][cH:7][c:8]1[O:9][c:10]1[c:11]2[c:12]([n:13][cH:14][cH:15]1)[cH:16][c:17]([I:19])[s:18]2.[O:79]1[CH2:80][CH2:81][O:82][CH2:83][CH2:84]1.[Pd:38]([Cl:39])[Cl:40].[c:41]1([P:42]([c:43]2[cH:44][cH:45][cH:46][cH:47][cH:48]2)[c:49]2[cH:50][cH:51][cH:52][cH:53][cH:54]2)[cH:55][cH:56][cH:57][cH:58][cH:59]1.[c:60]1([P:61]([c:62]2[cH:63][cH:64][cH:65][cH:66][cH:67]2)[c:68]2[cH:69][cH:70][cH:71][cH:72][cH:73]2)[cH:74][cH:75][cH:76][cH:77][cH:78]1>>[F:1][c:2]1[cH:3][c:4]([NH2:5])[cH:6][cH:7][c:8]1[O:9][c:10]1[c:11]2[c:12]([n:13][cH:14][cH:15]1)[cH:16][c:17](-[c:25]1[o:26][cH:27][cH:28][cH:29]1)[s:18]2

Participants

6

Reactant 5

HCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 312751,4-DioxaneHCID 43936882-(Tributylstannyl)furanHCID 584749503-Fluoro-4-((2-iodothieno[3,2-b]pyridin-7-yl)oxy)aniline

Product 1

HCID 673502153-Fluoro-4-(2-(furan-2-yl)thieno[3,2-b]pyridin-7-yloxy)benzenamine

Sources & evidence

ORD record
ord-41249e962cdb461fb17c58da7450a7e9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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