Hydrochloric Acid → 6-[[2-[1-[2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethyl]pyrrolidin-3-yl]propan-2-ylamino]methyl]-4H-pyrido[3,2-b][1,4]thiazin-3-one

HRID 949445Notes

Reaction equation

HRID 949445 reaction equation
[CH3:26][CH2:27][OH:28].[Cl:42][CH2:43][Cl:44].[ClH:1].[F:2][c:3]1[cH:4][n:5][c:6]2[cH:7][cH:8][c:9]([O:24][CH3:25])[n:10][c:11]2[c:12]1[CH2:13][CH2:14][N:15]1[CH2:16][CH:17]([C:20]([CH3:21])([CH3:22])[NH2:23])[CH2:18][CH2:19]1.[O:29]=[C:30]1[NH:31][c:32]2[c:33]([cH:36][cH:37][c:38]([CH:40]=[O:41])[n:39]2)[S:34][CH2:35]1>>[F:2][c:3]1[cH:4][n:5][c:6]2[cH:7][cH:8][c:9]([O:24][CH3:25])[n:10][c:11]2[c:12]1[CH2:13][CH2:14][N:15]1[CH2:16][CH:17]([C:20]([CH3:21])([CH3:22])[NH:23][CH2:40][c:38]2[cH:37][cH:36][c:33]3[c:32]([n:39]2)[NH:31][C:30](=[O:29])[CH2:35][S:34]3)[CH2:18][CH2:19]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 702EthanolHCID 6344DichloromethaneHCID 115935913-Oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazine-6-carbaldehydeHCID 178487912HCID 178487912, compound

Product 1

HCID 730612376-[[2-[1-[2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethyl]pyrrolidin-3-yl]propan-2-ylamino]methyl]-4H-pyrido[3,2-b][1,4]thiazin-3-one

Sources & evidence

ORD record
ord-57ae5570c84b4d79bd7301148e5134a2
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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