Sodium ion → 1-[(4-fluorophenyl)methyl]-N-[1-[2-(thiazolo[5,4-b]pyridin-2-ylthio)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine

HRID 949510Notes

Reaction equation

HRID 949510 reaction equation
[CH3:13][N:14]([CH3:15])[CH:16]=[O:17].[Cl:18][CH2:19][CH2:20][N:21]1[CH2:22][CH2:23][CH:24]([NH:27][c:28]2[n:29][c:30]3[c:31]([n:32]2[CH2:33][c:34]2[cH:35][cH:36][c:37]([F:40])[cH:38][cH:39]2)[cH:41][cH:42][cH:43][cH:44]3)[CH2:25][CH2:26]1.[H-:11].[Na+:12].[OH2:45].[n:1]1[c:2]([SH:10])[s:3][c:4]2[n:5][cH:6][cH:7][cH:8][c:9]12>>[n:1]1[c:2]([S:10][CH2:19][CH2:20][N:21]2[CH2:22][CH2:23][CH:24]([NH:27][c:28]3[n:29][c:30]4[c:31]([n:32]3[CH2:33][c:34]3[cH:35][cH:36][c:37]([F:40])[cH:38][cH:39]3)[cH:41][cH:42][cH:43][cH:44]4)[CH2:25][CH2:26]2)[s:3][c:4]2[n:5][cH:6][cH:7][cH:8][c:9]12

Participants

7

Reactant 6

HCID 923Sodium ionHCID 962WaterHCID 6228DimethylformamideHCID 166653HydrideHCID 12891727N-[1-(2-chloroethyl)-4-piperidinyl]-1-(4-fluorophenylmethyl)-1H-benzimidazol-2-amineHCID 178527801HCID 178527801, compound

Product 1

HCID 139831061-[(4-fluorophenyl)methyl]-N-[1-[2-(thiazolo[5,4-b]pyridin-2-ylthio)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine

Sources & evidence

ORD record
ord-d20a87dd558f46dba721a989bded1cc7
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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