Tetrahydrofuran → Propan-2-yl 4-[[7-[2-fluoro-4-(1-methylpyrrol-2-yl)phenyl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate
Reaction equation
[Br:1][c:2]1[cH:3][c:4]([F:30])[c:5]([N:8]2[CH2:9][CH2:10][c:11]3[c:12]2[n:13][cH:14][n:15][c:16]3[O:17][CH:18]2[CH2:19][CH2:20][N:21]([C:24](=[O:25])[O:26][CH:27]([CH3:28])[CH3:29])[CH2:22][CH2:23]2)[cH:6][cH:7]1.[CH2:50]1[O:51][CH2:52][CH2:53][CH2:54]1.[CH3:31][n:32]1[c:33]([Sn:37]([CH2:38][CH2:39][CH2:40][CH3:41])([CH2:42][CH2:43][CH2:44][CH3:45])[CH2:46][CH2:47][CH2:48][CH3:49])[cH:34][cH:35][cH:36]1>>[c:2]1(-[c:33]2[n:32]([CH3:31])[cH:36][cH:35][cH:34]2)[cH:3][c:4]([F:30])[c:5]([N:8]2[CH2:9][CH2:10][c:11]3[c:12]2[n:13][cH:14][n:15][c:16]3[O:17][CH:18]2[CH2:19][CH2:20][N:21]([C:24](=[O:25])[O:26][CH:27]([CH3:28])[CH3:29])[CH2:22][CH2:23]2)[cH:6][cH:7]1Participants
4
Sources & evidence
- ORD record
- ord-dc471dda64f348f395a9a947cabf33fd
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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