Methanol → 2-chloro-7-(4-fluorophenyl)-4-(2-methylpyrrolidin-1-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine

HRID 949662Notes

Reaction equation

HRID 949662 reaction equation
[CH3:19][CH:20]1[NH:21][CH2:22][CH2:23][CH2:24]1.[CH3:25][OH:26].[Cl:1][c:2]1[n:3][c:4]([Cl:18])[c:5]2[c:6]([n:7]1)[CH:8]([c:11]1[cH:12][cH:13][c:14]([F:17])[cH:15][cH:16]1)[CH2:9][CH2:10]2>>[Cl:1][c:2]1[n:3][c:4]([N:21]2[CH:20]([CH3:19])[CH2:24][CH2:23][CH2:22]2)[c:5]2[c:6]([n:7]1)[CH:8]([c:11]1[cH:12][cH:13][c:14]([F:17])[cH:15][cH:16]1)[CH2:9][CH2:10]2

Participants

4

Reactant 3

HCID 887MethanolHCID 130032-MethylpyrrolidineHCID 580754242,4-Dichloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[D]pyrimidine

Product 1

HCID 580752712-chloro-7-(4-fluorophenyl)-4-(2-methylpyrrolidin-1-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine

Sources & evidence

ORD record
ord-d145ac4c1eb248fdba8c574b730e05d4
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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