反应详情

A solution of 7-bromo-4-chloro-3-nitroquinoline (143.8 g, 0.5 mol) in 800 mL warm DMF was added to a stirred solution of ethylenediamine in 200 mL DMF at room temperature; the reaction was stirred at room temperature overnight. The reaction was quenched with 2 L water and stirred for an additional hour. Additional water was added, and the mixture was stirred overnight. A precipitate formed and was isolated by filtration and air-dried overnight on the filter funnel to provide N1-(7-bromo-3-nitroquinolin-4-yl)ethane-1,2-diamine as a yellow solid.

1. customThe reaction was quenched with 2 L water
2. stirringstirred for an additional hour
3. additionAdditional water was added
4. stirringthe mixture was stirred overnight
5. customA precipitate formed
6. customwas isolated by filtration
7. customair-dried overnight on the filter funnel