1,2-Dichloroethane → 4-[2-(4-hydroxymethyl-piperidin-1-yl)-2-oxo-ethyl]-6,6-dimethyl-morpholine-3-carboxylic acid (6-chloro-9H-beta-carbolin-8-yl)-amide

HRID 949743Notes

Reaction equation

HRID 949743 reaction equation
[CH2:38]([Cl:39])[CH2:40][Cl:41].[Cl:1][c:2]1[cH:3][c:4]2[c:5]3[cH:6][cH:7][n:8][cH:9][c:10]3[nH:11][c:12]2[c:13]([NH:15][C:16](=[O:17])[CH:18]2[N:19]([CH2:26][C:27](=[O:28])[OH:29])[CH2:20][C:21]([CH3:24])([CH3:25])[O:22][CH2:23]2)[cH:14]1.[NH:30]1[CH2:31][CH2:32][CH:33]([CH2:36][OH:37])[CH2:34][CH2:35]1.[OH2:42].[cH:43]1[cH:44][cH:45][n:46][cH:47][cH:48]1>>[Cl:1][c:2]1[cH:3][c:4]2[c:5]3[cH:6][cH:7][n:8][cH:9][c:10]3[nH:11][c:12]2[c:13]([NH:15][C:16](=[O:17])[CH:18]2[N:19]([CH2:26][C:27](=[O:28])[N:30]3[CH2:31][CH2:32][CH:33]([CH2:36][OH:37])[CH2:34][CH2:35]3)[CH2:20][C:21]([CH3:24])([CH3:25])[O:22][CH2:23]2)[cH:14]1

Participants

6

Reactant 5

HCID 111,2-DichloroethaneHCID 962WaterHCID 1049PyridineHCID 4207714-PiperidinemethanolHCID 59337527[5-(6-Chloro-9H-beta-carbolin-8-ylcarbamoyl)-2,2-dimethyl-morpholin-4-yl]-acetic acid

Product 1

HCID 671657504-[2-(4-hydroxymethyl-piperidin-1-yl)-2-oxo-ethyl]-6,6-dimethyl-morpholine-3-carboxylic acid (6-chloro-9H-beta-carbolin-8-yl)-amide

Sources & evidence

ORD record
ord-3fb0cd6742af43e9a4235f23827cac3c
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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