Sodium ion → tert-butyl (1-(4-(2-(6-oxo-6,11-dihydro-5H-benzo[e]pyrido[3,2-b][1,4]diazepin-5-yl)acetyl)phenyl)cyclobutyl)carbamate

HRID 949747Notes

Reaction equation

HRID 949747 reaction equation
[Br:19][CH2:20][C:21](=[O:22])[c:23]1[cH:24][cH:25][c:26]([C:29]2([NH:33][C:34]([O:35][C:36]([CH3:37])([CH3:38])[CH3:39])=[O:40])[CH2:30][CH2:31][CH2:32]2)[cH:27][cH:28]1.[CH3:41][N:42]([CH3:43])[CH:44]=[O:45].[H-:17].[Na+:18].[n:1]1[cH:2][cH:3][cH:4][c:5]2[c:11]1[NH:10][c:9]1[c:8]([cH:15][cH:14][cH:13][cH:12]1)[C:7](=[O:16])[NH:6]2>>[n:1]1[cH:2][cH:3][cH:4][c:5]2[c:11]1[NH:10][c:9]1[c:8]([cH:15][cH:14][cH:13][cH:12]1)[C:7](=[O:16])[N:6]2[CH2:20][C:21](=[O:22])[c:23]1[cH:24][cH:25][c:26]([C:29]2([NH:33][C:34]([O:35][C:36]([CH3:37])([CH3:38])[CH3:39])=[O:40])[CH2:30][CH2:31][CH2:32]2)[cH:27][cH:28]1

Participants

6

Reactant 5

HCID 923Sodium ionHCID 6228DimethylformamideHCID 701695,11-Dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-oneHCID 166653HydrideHCID 86664668Tert-butyl (1-(4-(2-bromoacetyl)phenyl)cyclobutyl)carbamate

Product 1

HCID 69087642tert-butyl (1-(4-(2-(6-oxo-6,11-dihydro-5H-benzo[e]pyrido[3,2-b][1,4]diazepin-5-yl)acetyl)phenyl)cyclobutyl)carbamate

Sources & evidence

ORD record
ord-6917942aa35f4f53a73051b11695d2eb
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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