Acetic Acid → ethyl N-(4-fluoroindol-3-ylmethyl)piperidin-4-ylcarboxylate

HRID 950009Notes

Reaction equation

HRID 950009 reaction equation
[C:24](=[O:25])([OH:26])[O-:27].[CH2:12]=[O:13].[CH3:35][C:36](=[O:37])[OH:38].[F:14][c:15]1[c:16]2[cH:17][cH:18][nH:19][c:20]2[cH:21][cH:22][cH:23]1.[NH:1]1[CH2:2][CH2:3][CH:4]([C:7](=[O:8])[O:9][CH2:10][CH3:11])[CH2:5][CH2:6]1.[Na+:28].[O:29]1[CH2:30][CH2:31][O:32][CH2:33][CH2:34]1>>[N:1]1([CH2:24][c:17]2[c:16]3[c:15]([F:14])[cH:23][cH:22][cH:21][c:20]3[nH:19][cH:18]2)[CH2:2][CH2:3][CH:4]([C:7](=[O:8])[O:9][CH2:10][CH3:11])[CH2:5][CH2:6]1

Participants

8

Reactant 7

HCID 176Acetic AcidHCID 712FormaldehydeHCID 769Bicarbonate IonHCID 923Sodium ionHCID 312751,4-DioxaneHCID 70770Ethyl 4-piperidinecarboxylateHCID 27745024-Fluoroindole

Product 1

HCID 19040931ethyl N-(4-fluoroindol-3-ylmethyl)piperidin-4-ylcarboxylate

Sources & evidence

ORD record
ord-e901392f71374c258b1645c9b91e7f0c
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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